loading...| Preferred Name | Promethazine Hydrochloride | |
| Synonyms |
Promethazine Hydrochloride N-(2-Dimethylaminopropyl-1)phenothiazine Hydrochloride Promethazine HCl PROMETHAZINE HYDROCHLORIDE Anergan Phencen Phenergan Prometh Prorex Provigan Remsed V-Gan Zipan-50 |
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| Definitions |
The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45907 |
|
| CAS_Registry |
58-33-3 |
|
| CHEBI_ID |
CHEBI:8462 |
|
| Chemical_Formula |
C17H20N2S.HCl |
|
| code |
C45907 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. |
|
| FDA_UNII_Code |
R61ZEH7I1I |
|
| FULL_SYN |
Promethazine Hydrochloride N-(2-Dimethylaminopropyl-1)phenothiazine Hydrochloride Promethazine HCl PROMETHAZINE HYDROCHLORIDE Anergan Phencen Phenergan Prometh Prorex Provigan Remsed V-Gan Zipan-50 |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Promethazine Hydrochloride |
|
| Legacy Concept Name |
Promethazine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
39567 |
|
| NSC Number |
231688 |
|
| PDQ_Closed_Trial_Search_ID |
39567 |
|
| PDQ_Open_Trial_Search_ID |
39567 |
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| Preferred_Name |
Promethazine Hydrochloride |
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| prefixIRI |
Thesaurus:C45907 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0546876 |
|
| subClassOf |