National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Domperidone
Synonyms

DOMPERIDONE

Domperidone

KW 5338

Motilium

R 33,812

Definitions

A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C454

CAS_Registry

57808-66-9

CHEBI_ID

CHEBI:31515

Chemical_Formula

C22H24ClN5O2

code

C454

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

HemOnc

DEFINITION

A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.

Display_Name

Domperidone

FDA_UNII_Code

5587267Z69

FULL_SYN

DOMPERIDONE

Domperidone

KW 5338

Motilium

R 33,812

label

Domperidone

Legacy Concept Name

Domperidone

NCI_Drug_Dictionary_ID

40071

NSC Number

299589

PDQ_Closed_Trial_Search_ID

40071

PDQ_Open_Trial_Search_ID

40071

Preferred_Name

Domperidone

prefixIRI

Thesaurus:C454

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0013015

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29710

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_31515 DRON LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040071 PDQ LOOM
http://purl.jp/bio/4/id/200906051882301133 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU026643 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017603 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D004294 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4025225 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP66331-7 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0005551 OMIT LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_31515 BIOMODELS LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171760 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.621.210 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907081070830485 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0013015 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-858C0 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387181004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/3626 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Domperidone GALEN LOOM
http://purl.obolibrary.org/obo/MESH_D004294 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C454 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/003454 NDDF LOOM
https://go.drugbank.com/drugs/DB01184 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4088 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/A03FA03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.103.370 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004294 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01184 FTC LOOM
http://purl.bioontology.org/ontology/RCD/x019W RCD LOOM