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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Diazoxide | |
| Synonyms |
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide DIAZOXIDE Diazoxide Proglycem SRG-95213 |
|
| Definitions |
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C428 |
|
| Accepted_Therapeutic_Use_For |
Malignant Hypertension
|
|
| CAS_Registry |
364-98-7
|
|
| CHEBI_ID |
CHEBI:4495
|
|
| Chemical_Formula |
C8H7ClN2O2S
|
|
| code |
C428
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.
|
|
| FDA_UNII_Code |
O5CB12L4FN
|
|
| FULL_SYN |
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide DIAZOXIDE Diazoxide Proglycem SRG-95213
|
|
| label |
Diazoxide
|
|
| Legacy Concept Name |
Diazoxide
|
|
| NCI_Drug_Dictionary_ID |
39290
|
|
| NSC Number |
64198 76130
|
|
| PDQ_Closed_Trial_Search_ID |
39290
|
|
| PDQ_Open_Trial_Search_ID |
39290
|
|
| Preferred_Name |
Diazoxide
|
|
| prefixIRI |
Thesaurus:C428
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0012022
|
|
| subClassOf |
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