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National Cancer Institute Thesaurus
| Preferred Name | Deferoxamine Mesylate | |
| Synonyms |
Deferoxamine B Deferoxamine Methanesulfonate DEFEROXAMINE MESYLATE Deferoxamine mesylate Deferoxamine Mesylate Desferrioxamine Mesylate Deferrioxamine B DFM Desferal |
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| Definitions |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C417 |
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| CAS_Registry |
138-14-7
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| CHEBI_ID |
CHEBI:31460
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| Chemical_Formula |
C25H48N6O8.CH4O3S
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|
| code |
C417
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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|
| DEFINITION |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome.
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| Display_Name |
Deferoxamine Mesylate
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| FDA_UNII_Code |
V9TKO7EO6K
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|
| FULL_SYN |
Deferoxamine B Deferoxamine Methanesulfonate DEFEROXAMINE MESYLATE Deferoxamine mesylate Deferoxamine Mesylate Desferrioxamine Mesylate Deferrioxamine B DFM Desferal
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Deferoxamine Mesylate
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|
| Legacy Concept Name |
Deferoxamine_Mesylate
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|
| Maps_To |
Deferoxamine Mesylate
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| NCI_Drug_Dictionary_ID |
41696
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| NSC Number |
644468
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| PDQ_Closed_Trial_Search_ID |
41696
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| PDQ_Open_Trial_Search_ID |
41696
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| Preferred_Name |
Deferoxamine Mesylate
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|
| prefixIRI |
Thesaurus:C417
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0011148
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| subClassOf |
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