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National Cancer Institute Thesaurus
| Preferred Name | Danazol | |
| Synonyms |
(17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol 17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole 1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol (17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol Bonzol Chronogyn Cyclomen DAN DANAZOL Danazol Danocrine Danol Danoval Ladogal Win 17757 Win-17757 Winobanin danazol |
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| Definitions |
A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C414 |
|
| ALT_DEFINITION |
A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer.
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| CAS_Registry |
17230-88-5
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|
| CHEBI_ID |
CHEBI:4315
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|
| Chemical_Formula |
C22H27NO2
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|
| code |
C414
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)
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|
| Display_Name |
Danazol
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|
| FDA_UNII_Code |
N29QWW3BUO
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|
| FULL_SYN |
(17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol 17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole 1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol (17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol Bonzol Chronogyn Cyclomen DAN DANAZOL Danazol Danocrine Danol Danoval Ladogal Win 17757 Win-17757 Winobanin danazol
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|
| label |
Danazol
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|
| Legacy Concept Name |
Danazol
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|
| NCI_Drug_Dictionary_ID |
39204
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|
| NSC Number |
270916
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|
| PDQ_Closed_Trial_Search_ID |
39204
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|
| PDQ_Open_Trial_Search_ID |
39204
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|
| Preferred_Name |
Danazol
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|
| prefixIRI |
Thesaurus:C414
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0010961
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|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2092 |
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