loading...| Preferred Name |
Dacarbazine |
|
| Synonyms |
1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)- Imidazole Carboxamide Dacarbazine - DTIC Biocarbazine Dimethyl Triazeno Imidazol Carboxamide Dimethyl Triazeno Imidazole Carboxamide Imidazole Carboxamide Dimethyltriazeno Dacarbazina Dacarbazine 5-(dimethyltriazeno)imidazole-4-carboxamide Dacarbazina Almirall DACARBAZINE Dimethyl (triazeno) imidazolecarboxamide Dimethyl-triazeno-imidazole-carboximide 5-(Dimethyltriazeno)imidazole-4-carboxamide 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide Imidazole carboxamide dacarbazine dimethyl-triazeno-imidazole carboxamide 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide 4-(Dimethyltriazeno)imidazole-5-carboxamide Asercit DIC DTIC DTIC-Dome Dacatic Dakarbazin Deticene Detimedac Fauldetic WR-139007 |
|
| Definitions |
A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C411 |
|
| Accepted_Therapeutic_Use_For |
Carcinoid cancer; Hodgkins disease; Islet cell carcinoma; Melanoma; Neuroblastoma; Soft tissue sarcoma |
|
| ALT_DEFINITION |
A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent. |
|
| CAS_Registry |
4342-03-4 |
|
| CHEBI_ID |
CHEBI:4305 |
|
| Chemical_Formula |
C6H10N6O |
|
| code |
C411 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|
| Display_Name |
Dacarbazine |
|
| FDA_UNII_Code |
7GR28W0FJI |
|
| FULL_SYN |
1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)- Imidazole Carboxamide Dacarbazine - DTIC Biocarbazine Dimethyl Triazeno Imidazol Carboxamide Dimethyl Triazeno Imidazole Carboxamide Imidazole Carboxamide Dimethyltriazeno Dacarbazina Dacarbazine 5-(dimethyltriazeno)imidazole-4-carboxamide Dacarbazina Almirall DACARBAZINE Dimethyl (triazeno) imidazolecarboxamide Dimethyl-triazeno-imidazole-carboximide 5-(Dimethyltriazeno)imidazole-4-carboxamide 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide Imidazole carboxamide dacarbazine dimethyl-triazeno-imidazole carboxamide 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide 4-(Dimethyltriazeno)imidazole-5-carboxamide Asercit DIC DTIC DTIC-Dome Dacatic Dakarbazin Deticene Detimedac Fauldetic WR-139007 |
|
| Is_Value_For_GDC_Property | ||
| label |
Dacarbazine |
|
| Legacy Concept Name |
Dacarbazine |
|
| Maps_To |
Dacarbazine |
|
| NCI_Drug_Dictionary_ID |
39768 |
|
| NSC Number |
45388 |
|
| PDQ_Closed_Trial_Search_ID |
39768 |
|
| PDQ_Open_Trial_Search_ID |
39768 |
|
| Preferred_Name |
Dacarbazine |
|
| prefixIRI |
Thesaurus:C411 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0010927 |
|
| subClassOf |