loading...| Preferred Name |
Diltiazem Hydrochloride |
|
| Synonyms |
Diltiazem HCl Diltiazem Hydrochloride DILTIAZEM HYDROCHLORIDE Cardizem |
|
| Definitions |
A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C398 |
|
| CAS_Registry |
33286-22-5 |
|
| CHEBI_ID |
CHEBI:645509 |
|
| Chemical_Formula |
C22H26N2O4S.HCl |
|
| code |
C398 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04) |
|
| FDA_UNII_Code |
OLH94387TE |
|
| FULL_SYN |
Diltiazem HCl Diltiazem Hydrochloride DILTIAZEM HYDROCHLORIDE Cardizem |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Diltiazem Hydrochloride |
|
| Legacy Concept Name |
Diltiazem_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
40122 |
|
| PDQ_Closed_Trial_Search_ID |
40122 |
|
| PDQ_Open_Trial_Search_ID |
40122 |
|
| Preferred_Name |
Diltiazem Hydrochloride |
|
| prefixIRI |
Thesaurus:C398 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0700940 |
|
| subClassOf |