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National Cancer Institute Thesaurus
| Preferred Name | Axitinib | |
| Synonyms |
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide AG-013736 AG013736 AXITINIB Axitinib Inlyta axitinib |
|
| Definitions |
An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38718 |
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| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein tyrosine kinase inhibitors.
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| CAS_Registry |
319460-85-0
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|
| Chemical_Formula |
C22H18N4OS
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|
| code |
C38718
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc
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|
| DEFINITION |
An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.
|
|
| Display_Name |
Axitinib
|
|
| FDA_UNII_Code |
C9LVQ0YUXG
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|
| FULL_SYN |
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide AG-013736 AG013736 AXITINIB Axitinib Inlyta axitinib
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Axitinib
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|
| Legacy Concept Name |
AG-013736
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|
| Maps_To |
Axitinib
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| NCI_Drug_Dictionary_ID |
352181
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|
| PDQ_Closed_Trial_Search_ID |
352181
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|
| PDQ_Open_Trial_Search_ID |
352181
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|
| Preferred_Name |
Axitinib
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|
| prefixIRI |
Thesaurus:C38718
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| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1700874
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|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159199 |
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