loading...| Preferred Name |
6-Aminonicotinamide |
|
| Synonyms |
Aminonicotinamide 6-Aminonicotinamide 6-AMINONICOTINAMIDE 6-AN U-8774 |
|
| Definitions |
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38127 |
|
| CAS_Registry |
329-89-5 |
|
| code |
C38127 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04) |
|
| FDA_UNII_Code |
D6FNW67F2B |
|
| FULL_SYN |
Aminonicotinamide 6-Aminonicotinamide 6-AMINONICOTINAMIDE 6-AN U-8774 |
|
| label |
6-Aminonicotinamide |
|
| Legacy Concept Name |
_6-Aminonicotinamide |
|
| NSC Number |
21206 |
|
| Preferred_Name |
6-Aminonicotinamide |
|
| prefixIRI |
Thesaurus:C38127 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0000610 |
|
| subClassOf |