loading...| Preferred Name | Clotrimazole | |
| Synonyms |
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole Gyne-Lotrimin Mycelex Troche CLOTRIMAZOLE Clotrimazole CLOT Lotrimin Mycelex |
|
| Definitions |
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C381 |
|
| CAS_Registry |
23593-75-1 |
|
| CHEBI_ID |
CHEBI:3764 |
|
| Chemical_Formula |
C22H17ClN2 |
|
| code |
C381 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. |
|
| FDA_UNII_Code |
G07GZ97H65 |
|
| FULL_SYN |
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole Gyne-Lotrimin Mycelex Troche CLOTRIMAZOLE Clotrimazole CLOT Lotrimin Mycelex |
|
| label |
Clotrimazole |
|
| Legacy Concept Name |
Clotrimazole |
|
| NCI_Drug_Dictionary_ID |
39116 |
|
| NSC Number |
257473 |
|
| PDQ_Closed_Trial_Search_ID |
39116 |
|
| PDQ_Open_Trial_Search_ID |
39116 |
|
| Preferred_Name |
Clotrimazole |
|
| prefixIRI |
Thesaurus:C381 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0009074 |
|
| subClassOf |