loading...| Preferred Name |
Carmustine |
|
| Synonyms |
Carmustinum N,N'-Bis(2-chloroethyl)-N-nitrosourea Bis(chloroethyl) Nitrosourea 1,3-Bis(2-chloroethyl)-1-nitrosourea Bis-Chloronitrosourea 1,3-Bis(beta-chloroethyl)-1-nitrosourea N,N'-bis(2-chloroethyl)-N-nitrosourea BCNU Becenum Becenun BiCNU CARMUSTINE Carmubris Carmustin Carmustine FDA 0345 Nitrourean Nitrumon SK 27702 SRI 1720 WR-139021 carmustine |
|
| Definitions |
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C349 |
|
| Accepted_Therapeutic_Use_For |
Brain tumors; colon cancer; lung cancer; lymphomas; Hodgkins and Non-Hodgkins; melanoma; multiple myeloma; mycosis fungoides |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents. |
|
| CAS_Registry |
154-93-8 |
|
| CHEBI_ID |
CHEBI:3423 |
|
| Chemical_Formula |
C5H9Cl2N3O2 |
|
| code |
C349 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) |
|
| Display_Name |
Carmustine |
|
| FDA_UNII_Code |
U68WG3173Y |
|
| FULL_SYN |
Carmustinum N,N'-Bis(2-chloroethyl)-N-nitrosourea Bis(chloroethyl) Nitrosourea 1,3-Bis(2-chloroethyl)-1-nitrosourea Bis-Chloronitrosourea 1,3-Bis(beta-chloroethyl)-1-nitrosourea N,N'-bis(2-chloroethyl)-N-nitrosourea BCNU Becenum Becenun BiCNU CARMUSTINE Carmubris Carmustin Carmustine FDA 0345 Nitrourean Nitrumon SK 27702 SRI 1720 WR-139021 carmustine |
|
| Is_Value_For_GDC_Property | ||
| label |
Carmustine |
|
| Legacy Concept Name |
Carmustine |
|
| Maps_To |
Carmustine |
|
| NCI_Drug_Dictionary_ID |
43027 |
|
| NSC Number |
409962 |
|
| PDQ_Closed_Trial_Search_ID |
43027 |
|
| PDQ_Open_Trial_Search_ID |
43027 |
|
| Preferred_Name |
Carmustine |
|
| prefixIRI |
Thesaurus:C349 |
|
| Semantic_Type |
Pharmacologic Substance Hazardous or Poisonous Substance |
|
| UMLS_CUI |
C0007257 |
|
| subClassOf |