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National Cancer Institute Thesaurus
| Preferred Name | Calcium Saccharate | |
| Synonyms |
Calcium Glucarate Calcium D-Saccharate Calcium Saccharate D-Glucaric Acid, Calcium Salt (1:1) Calcium D-Glucarate CALCIUM SACCHARATE Saccharated Lime 2,3,4,5-tetrahydroxy-1,6- dioxido-hexane-1,6-dione, Calcium Antacidin CGT |
|
| Definitions |
The calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. One of the key processes in which the human body eliminates toxic chemicals as well as hormones (such as estrogen) is by attaching glucuronic acid to them in the liver and then excreting the complex in the bile. When beta-glucuronidase breaks the bond, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Therefore, supplementing calcium glucarate may suppress the developments of hormone-dependent cancers. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C335 |
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| CAS_Registry |
5793-89-5
|
|
| Chemical_Formula |
C6H8O8.Ca.4H2O
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|
| code |
C335
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
The calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. One of the key processes in which the human body eliminates toxic chemicals as well as hormones (such as estrogen) is by attaching glucuronic acid to them in the liver and then excreting the complex in the bile. When beta-glucuronidase breaks the bond, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Therefore, supplementing calcium glucarate may suppress the developments of hormone-dependent cancers.
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|
| Display_Name |
Calcium Saccharate
|
|
| FDA_UNII_Code |
6AP9J91K4V
|
|
| FULL_SYN |
Calcium Glucarate Calcium D-Saccharate Calcium Saccharate D-Glucaric Acid, Calcium Salt (1:1) Calcium D-Glucarate CALCIUM SACCHARATE Saccharated Lime 2,3,4,5-tetrahydroxy-1,6- dioxido-hexane-1,6-dione, Calcium Antacidin CGT
|
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Calcium Saccharate
|
|
| Legacy Concept Name |
Calcium_Glucarate
|
|
| Maps_To |
Calcium Saccharate
|
|
| NCI_Drug_Dictionary_ID |
41803
|
|
| NSC Number |
122011
|
|
| PDQ_Closed_Trial_Search_ID |
41803
|
|
| PDQ_Open_Trial_Search_ID |
41803
|
|
| Preferred_Name |
Calcium Saccharate
|
|
| prefixIRI |
Thesaurus:C335
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0771997
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| subClassOf |
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