loading...| Preferred Name |
Type I Hypersensitivity |
|
| Synonyms |
Type I Hypersensitivity Reaction Immediate Hypersensitivity Type I Hypersensitivity Type I Immediate Hypersensitivity Reaction Type 1 Hypersensitivity Reaction Type 1 Hypersensitivity |
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| Definitions |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3116 |
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| ALT_DEFINITION |
An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually occur within an hour of exposure to an allergen. |
|
| code |
C3116 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 |
|
| Contributing_Source |
MedDRA NICHD |
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| DEFINITION |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
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| FULL_SYN |
Type I Hypersensitivity Reaction Immediate Hypersensitivity Type I Hypersensitivity Type I Immediate Hypersensitivity Reaction Type 1 Hypersensitivity Reaction Type 1 Hypersensitivity |
|
| label |
Type I Hypersensitivity |
|
| Legacy Concept Name |
Immediate_Hypersensitivity |
|
| Maps_To |
Immediate hypersensitivity reaction |
|
| Preferred_Name |
Type I Hypersensitivity |
|
| prefixIRI |
Thesaurus:C3116 |
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| Semantic_Type |
Disease or Syndrome |
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| UMLS_CUI |
C0020523 |
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| subClassOf |