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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Zolpidem Tartrate | |
| Synonyms |
Zolpidem Tartrate ZOLPIDEM TARTRATE Ambien Intermezzo zolpidem |
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| Definitions |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29553 |
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| ALT_DEFINITION |
A drug used to treat insomnia (inability to sleep), and anxiety. It is a type of imidazopyridine (sedative hypnotic).
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| CAS_Registry |
99294-93-6
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|
| CHEBI_ID |
CHEBI:10126
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| Chemical_Formula |
2C19H21N3O.C4H6O6
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|
| code |
C29553
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity.
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| FDA_UNII_Code |
WY6W63843K
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|
| FULL_SYN |
Zolpidem Tartrate ZOLPIDEM TARTRATE Ambien Intermezzo zolpidem
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Zolpidem Tartrate
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|
| Legacy Concept Name |
Zolpidem_Tartrate
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| NCI_Drug_Dictionary_ID |
370808
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| PDQ_Closed_Trial_Search_ID |
370808
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| PDQ_Open_Trial_Search_ID |
370808
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| Preferred_Name |
Zolpidem Tartrate
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|
| prefixIRI |
Thesaurus:C29553
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0724725
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| subClassOf |
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