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National Cancer Institute Thesaurus
| Preferred Name | Triptorelin Pamoate | |
| Synonyms |
6-D-Tryptophan-, 4,4'Mmethylenebis(3-hydroxy-2-naphthalenecarboxylate) (Salt) Triptorelin Pamoate TRIPTORELIN PAMOATE Triptorelin Embonate Diphereline Decapeptyl Pamorelin Trelstar |
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| Definitions |
The pamoate salt of triptorelin, a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion after prolonged administration. After chronic, continuous administration, a sustained decrease in LH, FSH and testicular and ovarian steroidogenesis is observed. The serum testosterone concentration may fall to levels typically seen in surgically castrated men. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29523 |
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| ALT_DEFINITION |
A drug that is used to treat advanced prostate cancer, and is being studied in the treatment of breast cancer. It belongs to the family of hormonal drugs called gonadotropin-releasing hormone analogs.
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| CAS_Registry |
124508-66-3
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| Chemical_Formula |
C64H82N18O13.C23H16O6
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| code |
C29523
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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| DEFINITION |
The pamoate salt of triptorelin, a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion after prolonged administration. After chronic, continuous administration, a sustained decrease in LH, FSH and testicular and ovarian steroidogenesis is observed. The serum testosterone concentration may fall to levels typically seen in surgically castrated men. (NCI04)
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| Display_Name |
Triptorelin Pamoate
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| FDA_UNII_Code |
08AN7WA2G0
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| FULL_SYN |
6-D-Tryptophan-, 4,4'Mmethylenebis(3-hydroxy-2-naphthalenecarboxylate) (Salt) Triptorelin Pamoate TRIPTORELIN PAMOATE Triptorelin Embonate Diphereline Decapeptyl Pamorelin Trelstar
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Triptorelin Pamoate
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|
| Legacy Concept Name |
Triptorelin_Pamoate
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| Maps_To |
Triptorelin Pamoate
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| NCI_Drug_Dictionary_ID |
468834
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| NSC Number |
724666
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| PDQ_Closed_Trial_Search_ID |
468834
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| PDQ_Open_Trial_Search_ID |
468834
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| Preferred_Name |
Triptorelin Pamoate
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| prefixIRI |
Thesaurus:C29523
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1137102
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| subClassOf |
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