Gonadotropin-releasing Hormone Analog

LH-RH Analogs

Gonadotropin-Releasing Hormone Analogue

LH-RH agonist

GnRH Agonist

luteinizing hormone-releasing hormone agonist

LHRH Agonist

Luteinizing Hormone-Releasing Hormone Analog

Gonadotropin-releasing Hormone Analog

gonadotropin-releasing hormone agonist

Gonadotropin-Releasing Hormone Agonist

GnRH Analog

A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1910

A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, gonadotropin-releasing hormone agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone. Some gonadotropin-releasing hormone agonists are used to treat prostate cancer. Also called GnRH agonist, LH-RH agonist, and luteinizing hormone-releasing hormone agonist.

C1910

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

CTRP

GDC

A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form.

Gonadotropin-releasing Hormone Analog

LH-RH Analogs

Gonadotropin-Releasing Hormone Analogue

LH-RH agonist

GnRH Agonist

luteinizing hormone-releasing hormone agonist

LHRH Agonist

Luteinizing Hormone-Releasing Hormone Analog

Gonadotropin-releasing Hormone Analog

gonadotropin-releasing hormone agonist

Gonadotropin-Releasing Hormone Agonist

GnRH Analog

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

Gonadotropin-releasing Hormone Analog

Luteinizing_Hormone-releasing_Hormone_Agonist

Gonadotropin-releasing Hormone Analog

42628

42628

42628

Gonadotropin-releasing Hormone Analog

Thesaurus:C1910

Pharmacologic Substance

C1268900

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C548