National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1910
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1910
Preferred Name

Gonadotropin-releasing Hormone Analog
Definitions
A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form.
Synonyms
LH-RH Analogs
Gonadotropin-Releasing Hormone Analogue
LH-RH agonist
GnRH Agonist
luteinizing hormone-releasing hormone agonist
LHRH Agonist
Luteinizing Hormone-Releasing Hormone Analog
Gonadotropin-releasing Hormone Analog
gonadotropin-releasing hormone agonist
Gonadotropin-Releasing Hormone Agonist
GnRH Analog
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Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Gonadotropin-releasing Hormone Analog
Maps_To
Gonadotropin-releasing Hormone Analog
Legacy Concept Name
Luteinizing_Hormone-releasing_Hormone_Agonist
NCI_Drug_Dictionary_ID
42628
Is_Value_For_GDC_Property
PDQ_Closed_Trial_Search_ID
42628
Preferred_Name
Gonadotropin-releasing Hormone Analog
Display_Name
Gonadotropin-releasing Hormone Analog
Semantic_Type
Pharmacologic Substance
prefixIRI
Thesaurus:C1910
DEFINITION
A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form.
UMLS_CUI
C1268900
code
C1910
subClassOf
type
FULL_SYN
LH-RH Analogs
Gonadotropin-Releasing Hormone Analogue
LH-RH agonist
GnRH Agonist
luteinizing hormone-releasing hormone agonist
LHRH Agonist
Luteinizing Hormone-Releasing Hormone Analog
Gonadotropin-releasing Hormone Analog
gonadotropin-releasing hormone agonist
Gonadotropin-Releasing Hormone Agonist
GnRH Analog
See more
See less
ALT_DEFINITION
A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, gonadotropin-releasing hormone agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone. Some gonadotropin-releasing hormone agonists are used to treat prostate cancer. Also called GnRH agonist, LH-RH agonist, and luteinizing hormone-releasing hormone agonist.
PDQ_Open_Trial_Search_ID
42628
Contributing_Source
CTRP
GDC
Concept_In_Subset
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