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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Tolazamide | |
| Synonyms |
4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea Norglycin TOLAZAMIDE Tolazamide Tolinase U-17835 |
|
| Definitions |
An intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. Tolazamide is converted into five major metabolites that are excreted into the urine. Tolazamide is more potent than tolbutamide and similar in potency to chlorpropamide on a milligram basis. This agent may cause cholestatic jaundice. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29502 |
|
| CAS_Registry |
1156-19-0
|
|
| Chemical_Formula |
C14H21N3O3S
|
|
| code |
C29502
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
An intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. Tolazamide is converted into five major metabolites that are excreted into the urine. Tolazamide is more potent than tolbutamide and similar in potency to chlorpropamide on a milligram basis. This agent may cause cholestatic jaundice.
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|
| FDA_UNII_Code |
9LT1BRO48Q
|
|
| FULL_SYN |
4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea Norglycin TOLAZAMIDE Tolazamide Tolinase U-17835
|
|
| label |
Tolazamide
|
|
| Legacy Concept Name |
Tolazamide
|
|
| NCI_Drug_Dictionary_ID |
775372
|
|
| NSC Number |
70762
|
|
| PDQ_Closed_Trial_Search_ID |
775372
|
|
| PDQ_Open_Trial_Search_ID |
775372
|
|
| Preferred_Name |
Tolazamide
|
|
| prefixIRI |
Thesaurus:C29502
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0040372
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|
| subClassOf |
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