loading...| Preferred Name |
Thioridazine Hydrochloride |
|
| Synonyms |
Thioridazine Hydrochloride THIORIDAZINE HYDROCHLORIDE |
|
| Definitions |
The hydrochloride salt form of thioridazine, a piperidine phenothiazine derivative and a dopamine antagonist with antipsychotic property. Thioridazine hydrochloride binds to mesolimbic postsynaptic dopamine receptor D2, thereby decreasing dopamine activity leading to decreased psychotic effects, such as hallucinations and delusions. In addition, this agent binds to serotonin 5-HT2 receptors, resulting in decreased serotonin activity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29498 |
|
| CAS_Registry |
130-61-0 |
|
| CHEBI_ID |
CHEBI:48566 |
|
| Chemical_Formula |
C21H26N2S2.HCl |
|
| code |
C29498 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt form of thioridazine, a piperidine phenothiazine derivative and a dopamine antagonist with antipsychotic property. Thioridazine hydrochloride binds to mesolimbic postsynaptic dopamine receptor D2, thereby decreasing dopamine activity leading to decreased psychotic effects, such as hallucinations and delusions. In addition, this agent binds to serotonin 5-HT2 receptors, resulting in decreased serotonin activity. |
|
| Display_Name |
Thioridazine Hydrochloride |
|
| FDA_UNII_Code |
4WCI67NK8M |
|
| FULL_SYN |
Thioridazine Hydrochloride THIORIDAZINE HYDROCHLORIDE |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Thioridazine Hydrochloride |
|
| Legacy Concept Name |
Thioridazine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
746026 |
|
| NSC Number |
186060 |
|
| PDQ_Closed_Trial_Search_ID |
746026 |
|
| PDQ_Open_Trial_Search_ID |
746026 |
|
| Preferred_Name |
Thioridazine Hydrochloride |
|
| prefixIRI |
Thesaurus:C29498 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0700499 |
|
| subClassOf |