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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Temazepam | |
| Synonyms |
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one Oxydiazepam Ro 5-5345 TEMAZEPAM Temazepam |
|
| Definitions |
A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29488 |
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| CAS_Registry |
846-50-4
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|
| Chemical_Formula |
C16H13ClN2O2
|
|
| code |
C29488
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|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.
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|
| FDA_UNII_Code |
CHB1QD2QSS
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|
| FULL_SYN |
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one Oxydiazepam Ro 5-5345 TEMAZEPAM Temazepam
|
|
| label |
Temazepam
|
|
| Legacy Concept Name |
Temezepam
|
|
| NSC Number |
246303
|
|
| Preferred_Name |
Temazepam
|
|
| prefixIRI |
Thesaurus:C29488
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0039468
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| subClassOf |
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