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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Pentamidine Isethionate | |
| Synonyms |
Pentacarinat Pentamidine Isethionate pentamidine isethionate PENTAMIDINE ISETHIONATE Pentam |
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| Definitions |
A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29349 |
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| ALT_DEFINITION |
A drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.
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| CAS_Registry |
140-64-7
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| CHEBI_ID |
CHEBI:7977
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| Chemical_Formula |
C19H24N4O2.2C2H6O4S
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|
| code |
C29349
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)
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| FDA_UNII_Code |
V2P3K60DA2
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| FULL_SYN |
Pentacarinat Pentamidine Isethionate pentamidine isethionate PENTAMIDINE ISETHIONATE Pentam
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Pentamidine Isethionate
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| Legacy Concept Name |
Pentamidine_Isethionate
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| NCI_Drug_Dictionary_ID |
778947
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| NSC Number |
620107
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| PDQ_Closed_Trial_Search_ID |
778947
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| PDQ_Open_Trial_Search_ID |
778947
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| Preferred_Name |
Pentamidine Isethionate
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| prefixIRI |
Thesaurus:C29349
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0030864
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| subClassOf |
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