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National Cancer Institute Thesaurus
| Preferred Name | Oxycodone | |
| Synonyms |
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone SR OXYCODONE Oxycodone |
|
| Definitions |
A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29309 |
|
| CAS_Registry |
76-42-6
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|
| CHEBI_ID |
CHEBI:7852
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|
| Chemical_Formula |
C18H21NO4
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|
| code |
C29309
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability.
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|
| Display_Name |
Oxycodone
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|
| FDA_UNII_Code |
CD35PMG570
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|
| FULL_SYN |
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone SR OXYCODONE Oxycodone
|
|
| Has_Salt_Form | ||
| label |
Oxycodone
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|
| Legacy Concept Name |
Oxycodone
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| NSC Number |
19043
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|
| Preferred_Name |
Oxycodone
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|
| prefixIRI |
Thesaurus:C29309
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0030049
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| subClassOf |
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