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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Nisoldipine | |
| Synonyms |
Nisoldipine SR Nisoldipine NISOLDIPINE Sular |
|
| Definitions |
A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29291 |
|
| Accepted_Therapeutic_Use_For |
Hypertension
|
|
| CAS_Registry |
63675-72-9
|
|
| Chemical_Formula |
C20H24N2O6
|
|
| code |
C29291
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
|
|
| FDA_UNII_Code |
4I8HAB65SZ
|
|
| FULL_SYN |
Nisoldipine SR Nisoldipine NISOLDIPINE Sular
|
|
| label |
Nisoldipine
|
|
| Legacy Concept Name |
Nisoldipine
|
|
| Preferred_Name |
Nisoldipine
|
|
| prefixIRI |
Thesaurus:C29291
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0028116
|
|
| subClassOf |
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