loading...| Preferred Name |
Milrinone Lactate |
|
| Synonyms |
MILRINONE LACTATE Milrinone Lactate Primacor |
|
| Definitions |
The lactate salt form of milrinone, a cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29263 |
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| CAS_Registry |
100286-97-3 |
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| CHEBI_ID |
CHEBI:34850 |
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| Chemical_Formula |
C12H9N3O.C3H6O3 |
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| code |
C29263 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The lactate salt form of milrinone, a cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle. |
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| FDA_UNII_Code |
9K8XR81MO8 |
|
| FULL_SYN |
MILRINONE LACTATE Milrinone Lactate Primacor |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Milrinone Lactate |
|
| Legacy Concept Name |
Milrinone_Lactate |
|
| Preferred_Name |
Milrinone Lactate |
|
| prefixIRI |
Thesaurus:C29263 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0600487 |
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| subClassOf |