National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Meclizine Hydrochloride

Synonyms

Meclizine Hydrochloride

Meclizine HCl

MECLIZINE HYDROCHLORIDE

1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate

Meclizine Dihydrochloride Monohydrate

Antivert

Bonine

Definitions

The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29245

CAS_Registry

31884-77-2

Chemical_Formula

C25H27ClN2.2HCl.H2O

code

C29245

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.

FDA_UNII_Code

HDP7W44CIO

FULL_SYN

Meclizine Hydrochloride

Meclizine HCl

MECLIZINE HYDROCHLORIDE

1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate

Meclizine Dihydrochloride Monohydrate

Antivert

Bonine

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61610

label

Meclizine Hydrochloride

Legacy Concept Name

Meclizine_Hydrochloride

NCI_Drug_Dictionary_ID

793974

NSC Number

169189

PDQ_Closed_Trial_Search_ID

793974

PDQ_Open_Trial_Search_ID

793974

Preferred_Name

Meclizine Hydrochloride

prefixIRI

Thesaurus:C29245

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0282227

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C267

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29578

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