loading...| Preferred Name | Labetalol | |
| Synonyms |
LABETALOL Labetalol |
|
| Definitions |
A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29146 |
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| CAS_Registry |
36894-69-6 |
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| CHEBI_ID |
CHEBI:6343 |
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| Chemical_Formula |
C19H24N2O3 |
|
| code |
C29146 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| FDA_UNII_Code |
R5H8897N95 |
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| FULL_SYN |
LABETALOL Labetalol |
|
| Has_Salt_Form | ||
| label |
Labetalol |
|
| Legacy Concept Name |
Labetalol |
|
| Preferred_Name |
Labetalol |
|
| prefixIRI |
Thesaurus:C29146 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0022860 |
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| subClassOf |