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National Cancer Institute Thesaurus
| Preferred Name | Ketamine Hydrochloride | |
| Synonyms |
Ketamine HCl KETAMINE HYDROCHLORIDE Ketamine Hydrochloride ketamine hydrochloride Ketalar Ketamine |
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| Definitions |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29142 |
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| ALT_DEFINITION |
A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketalar blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.
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| CAS_Registry |
1867-66-9
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| CHEBI_ID |
CHEBI:650657
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| Chemical_Formula |
C13H16ClNO.HCl
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|
| code |
C29142
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159412 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
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| Contributing_Source |
CPTAC CTRP FDA
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|
| DEFINITION |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.
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| Display_Name |
Ketamine Hydrochloride
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| FDA_UNII_Code |
O18YUO0I83
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| FULL_SYN |
Ketamine HCl KETAMINE HYDROCHLORIDE Ketamine Hydrochloride ketamine hydrochloride Ketalar Ketamine
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Ketamine Hydrochloride
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| Legacy Concept Name |
Ketamine_Hydrochloride
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| NCI_Drug_Dictionary_ID |
452041
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| PDQ_Closed_Trial_Search_ID |
452041
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| PDQ_Open_Trial_Search_ID |
452041
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| Preferred_Name |
Ketamine Hydrochloride
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| prefixIRI |
Thesaurus:C29142
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0700541
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| subClassOf |
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