loading...| Preferred Name |
Ipratropium Bromide |
|
| Synonyms |
(8R)-3alpha-Hydroxy-8-isopropyl-1alpha H,5alphaH-tropanium Bromide (+-)-tropate Monohydrate IPRATROPIUM BROMIDE Atrovent HFA Ipratropium Bromide Ipratropium Bromide Hydrate Atrovent |
|
| Definitions |
The bromide salt form of ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29128 |
|
| CAS_Registry |
66985-17-9 |
|
| CHEBI_ID |
CHEBI:5957 |
|
| Chemical_Formula |
C20H30NO3.Br.H2O |
|
| code |
C29128 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The bromide salt form of ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation. |
|
| FDA_UNII_Code |
J697UZ2A9J |
|
| FULL_SYN |
(8R)-3alpha-Hydroxy-8-isopropyl-1alpha H,5alphaH-tropanium Bromide (+-)-tropate Monohydrate IPRATROPIUM BROMIDE Atrovent HFA Ipratropium Bromide Ipratropium Bromide Hydrate Atrovent |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Ipratropium Bromide |
|
| Legacy Concept Name |
Ipratropium_Bromide |
|
| Preferred_Name |
Ipratropium Bromide |
|
| prefixIRI |
Thesaurus:C29128 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700580 |
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| subClassOf |