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National Cancer Institute Thesaurus
| Preferred Name | Insulin Lispro | |
| Synonyms |
INSULIN LISPRO Insulin Lispro Humalog |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29123 |
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| CAS_Registry |
133107-64-9
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|
| Chemical_Formula |
C257H383N65O77S6
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|
| code |
C29123
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04)
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|
| FDA_UNII_Code |
GFX7QIS1II
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|
| FULL_SYN |
INSULIN LISPRO Insulin Lispro Humalog
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|
| label |
Insulin Lispro
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|
| Legacy Concept Name |
Lispo_Insulin
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|
| Preferred_Name |
Insulin Lispro
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|
| prefixIRI |
Thesaurus:C29123
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0293359
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| subClassOf |
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