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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Hydroxyzine | |
| Synonyms |
Hydroxyzine HYDROXYZINE |
|
| Definitions |
A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29103 |
|
| CAS_Registry |
68-88-2
|
|
| CHEBI_ID |
CHEBI:5818
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|
| Chemical_Formula |
C21H27ClN2O2
|
|
| code |
C29103
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc
|
|
| DEFINITION |
A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
|
|
| FDA_UNII_Code |
30S50YM8OG
|
|
| FULL_SYN |
Hydroxyzine HYDROXYZINE
|
|
| Has_Salt_Form | ||
| label |
Hydroxyzine
|
|
| Legacy Concept Name |
Hydroxyzine
|
|
| NSC Number |
169188
|
|
| Preferred_Name |
Hydroxyzine
|
|
| prefixIRI |
Thesaurus:C29103
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0020404
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|
| subClassOf |
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