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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Flunisolide | |
| Synonyms |
Flunisolide FLUNISOLIDE |
|
| Definitions |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Flunisolide is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29054 |
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| CAS_Registry |
77326-96-6
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|
| Chemical_Formula |
2C24H31FO6.H2O
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|
| code |
C29054
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|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Flunisolide is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation.
|
|
| FDA_UNII_Code |
QK4DYS664X
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|
| FULL_SYN |
Flunisolide FLUNISOLIDE
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|
| label |
Flunisolide
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|
| Legacy Concept Name |
Flunisolide
|
|
| Preferred_Name |
Flunisolide
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|
| prefixIRI |
Thesaurus:C29054
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0060501
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|
| subClassOf |
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