loading...| Preferred Name |
Doxazosin Mesylate |
|
| Synonyms |
doxazosin mesylate Doxazosin Mesylate DOXAZOSIN MESYLATE Cardura doxazosin |
|
| Definitions |
The mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (BPH). This may improve BPH symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29005 |
|
| ALT_DEFINITION |
A drug used to treat high blood pressure and urinary problems caused by an enlarged prostate. It relaxes muscle tissue in blood vessels and in the prostate. Cardura is a type of alpha blocker. |
|
| CAS_Registry |
77883-43-3 |
|
| CHEBI_ID |
CHEBI:4709 |
|
| Chemical_Formula |
C23H25N5O5.CH4O3S |
|
| code |
C29005 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (BPH). This may improve BPH symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance. |
|
| FDA_UNII_Code |
86P6PQK0MU |
|
| FULL_SYN |
doxazosin mesylate Doxazosin Mesylate DOXAZOSIN MESYLATE Cardura doxazosin |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Doxazosin Mesylate |
|
| Legacy Concept Name |
Doxazosin_Mesylate |
|
| NCI_Drug_Dictionary_ID |
703207 |
|
| PDQ_Closed_Trial_Search_ID |
703207 |
|
| PDQ_Open_Trial_Search_ID |
703207 |
|
| Preferred_Name |
Doxazosin Mesylate |
|
| prefixIRI |
Thesaurus:C29005 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0678136 |
|
| subClassOf |