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National Cancer Institute Thesaurus
| Preferred Name | Cefoxitin Sodium | |
| Synonyms |
CEFOXITIN SODIUM Cefoxitin Sodium Mefoxin |
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| Definitions |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28915 |
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| CAS_Registry |
33564-30-6
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|
| Chemical_Formula |
C16H16N3O7S2.Na
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|
| code |
C28915
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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| DEFINITION |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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| Display_Name |
Cefoxitin Sodium
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| FDA_UNII_Code |
Q68050H03T
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|
| FULL_SYN |
CEFOXITIN SODIUM Cefoxitin Sodium Mefoxin
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Cefoxitin Sodium
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| Legacy Concept Name |
Cefoxitin_Sodium
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| NCI_Drug_Dictionary_ID |
787118
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| PDQ_Closed_Trial_Search_ID |
787118
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| PDQ_Open_Trial_Search_ID |
787118
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| Preferred_Name |
Cefoxitin Sodium
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| prefixIRI |
Thesaurus:C28915
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0700446
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| subClassOf |
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