loading...| Preferred Name | Benazepril Hydrochloride | |
| Synonyms |
Benazepril Hydrochloride Benazepril HCl BENAZEPRIL HYDROCHLORIDE CGS14824A Lotensin |
|
| Definitions |
The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28862 |
|
| CAS_Registry |
86541-74-4 |
|
| Chemical_Formula |
C24H28N2O5.ClH |
|
| code |
C28862 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| Display_Name |
Benazepril Hydrochloride |
|
| FDA_UNII_Code |
N1SN99T69T |
|
| FULL_SYN |
Benazepril Hydrochloride Benazepril HCl BENAZEPRIL HYDROCHLORIDE CGS14824A Lotensin |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| label |
Benazepril Hydrochloride |
|
| Legacy Concept Name |
Benazepril_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
686949 |
|
| PDQ_Closed_Trial_Search_ID |
686949 |
|
| PDQ_Open_Trial_Search_ID |
686949 |
|
| Preferred_Name |
Benazepril Hydrochloride |
|
| prefixIRI |
Thesaurus:C28862 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0770917 |
|
| subClassOf |