loading...| Preferred Name |
Azithromycin |
|
| Synonyms |
AZITHROMYCIN, UNSPECIFIED FORM N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A Azithromycin (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentade AzaSite CP 62993 XZ-450 Zithromax |
|
| Definitions |
An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28844 |
|
| CAS_Registry |
83905-01-5 |
|
| code |
C28844 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. |
|
| Display_Name |
Azithromycin |
|
| FDA_UNII_Code |
F94OW58Y8V |
|
| FULL_SYN |
AZITHROMYCIN, UNSPECIFIED FORM N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A Azithromycin (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentade AzaSite CP 62993 XZ-450 Zithromax |
|
| label |
Azithromycin |
|
| Legacy Concept Name |
Azithromycin |
|
| NCI_Drug_Dictionary_ID |
695416 |
|
| NSC Number |
643732 |
|
| PDQ_Closed_Trial_Search_ID |
695416 |
|
| PDQ_Open_Trial_Search_ID |
695416 |
|
| Preferred_Name |
Azithromycin |
|
| prefixIRI |
Thesaurus:C28844 |
|
| Semantic_Type |
Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0052796 |
|
| subClassOf |