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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Astemizole | |
| Synonyms |
1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole 1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)eth l)-4-piperidinyl)- ASTEMIZOLE Astemizole Hismanal Paralergin R 42512 R 43,512 Retolen |
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| Definitions |
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28834 |
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| CAS_Registry |
68844-77-9
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|
| CHEBI_ID |
CHEBI:2896
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| Chemical_Formula |
C28H31FN4O
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|
| code |
C28834
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria. (NCI04)
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| FDA_UNII_Code |
7HU6337315
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|
| FULL_SYN |
1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole 1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)eth l)-4-piperidinyl)- ASTEMIZOLE Astemizole Hismanal Paralergin R 42512 R 43,512 Retolen
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|
| label |
Astemizole
|
|
| Legacy Concept Name |
Astemizole
|
|
| Preferred_Name |
Astemizole
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|
| prefixIRI |
Thesaurus:C28834
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0699606
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| subClassOf |
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