loading...| Preferred Name | Topotecan Hydrochloride | |
| Synonyms |
SKF S-104864-A (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride Hycamptamine Topotecan hydrochloride Topotecan Hydrochloride TOPOTECAN HYDROCHLORIDE topotecan hydrochloride (oral) topotecan hydrochloride Topotecan HCl Evotopin Hycamtin Potactasol Topotec |
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| Definitions |
The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2828 |
|
| Accepted_Therapeutic_Use_For |
Small Cell Lung Carcinoma; Cervical Cancer |
|
| ALT_DEFINITION |
A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Hycamtin is a type of topoisomerase inhibitor. |
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| CAS_Registry |
119413-54-6 |
|
| Chemical_Formula |
C23H23N3O5.HCl |
|
| code |
C2828 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. |
|
| Display_Name |
Topotecan Hydrochloride |
|
| FDA_UNII_Code |
956S425ZCY |
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| FULL_SYN |
SKF S-104864-A (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride Hycamptamine Topotecan hydrochloride Topotecan Hydrochloride TOPOTECAN HYDROCHLORIDE topotecan hydrochloride (oral) topotecan hydrochloride Topotecan HCl Evotopin Hycamtin Potactasol Topotec |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Topotecan Hydrochloride |
|
| Legacy Concept Name |
Topotecan_Hydrochloride |
|
| Maps_To |
Topotecan Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
41185 |
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| NSC Number |
609699 |
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| PDQ_Closed_Trial_Search_ID |
41185 |
|
| PDQ_Open_Trial_Search_ID |
41185 |
|
| Preferred_Name |
Topotecan Hydrochloride |
|
| prefixIRI |
Thesaurus:C2828 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0886549 |
|
| subClassOf |