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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Buspirone Hydrochloride | |
| Synonyms |
BUSPIRONE HYDROCHLORIDE Buspirone Hydrochloride |
|
| Definitions |
The hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26641 |
|
| Accepted_Therapeutic_Use_For |
alcohol abuse; anxiety; depression; migraine prophylaxis; smoking cessation; panic disorder.
|
|
| CAS_Registry |
33386-08-2
|
|
| CHEBI_ID |
CHEBI:3224
|
|
| Chemical_Formula |
C21H31N5O2.HCl
|
|
| code |
C26641
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
The hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects.
|
|
| Display_Name |
Buspirone Hydrochloride
|
|
| FDA_UNII_Code |
207LT9J9OC
|
|
| FULL_SYN |
BUSPIRONE HYDROCHLORIDE Buspirone Hydrochloride
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Buspirone Hydrochloride
|
|
| Legacy Concept Name |
Buspirone
|
|
| NCI_Drug_Dictionary_ID |
270391
|
|
| PDQ_Closed_Trial_Search_ID |
270391
|
|
| PDQ_Open_Trial_Search_ID |
270391
|
|
| Preferred_Name |
Buspirone Hydrochloride
|
|
| prefixIRI |
Thesaurus:C26641
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0700444
|
|
| subClassOf |
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