loading...| Preferred Name |
Pirfenidone |
|
| Synonyms |
PIRFENIDONE pirfenidone Pirfenidone |
|
| Definitions |
An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2635 |
|
| ALT_DEFINITION |
A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents. |
|
| CAS_Registry |
53179-13-8 |
|
| Chemical_Formula |
C12H11NO |
|
| code |
C2635 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04) |
|
| FDA_UNII_Code |
D7NLD2JX7U |
|
| FULL_SYN |
PIRFENIDONE pirfenidone Pirfenidone |
|
| Is_Value_For_GDC_Property | ||
| label |
Pirfenidone |
|
| Legacy Concept Name |
Pirfenidone |
|
| Maps_To |
Pirfenidone |
|
| NCI_Drug_Dictionary_ID |
38334 |
|
| PDQ_Closed_Trial_Search_ID |
38334 |
|
| PDQ_Open_Trial_Search_ID |
38334 |
|
| Preferred_Name |
Pirfenidone |
|
| prefixIRI |
Thesaurus:C2635 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0298067 |
|
| subClassOf |