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National Cancer Institute Thesaurus
| Preferred Name | Digitoxin | |
| Synonyms |
Crystodigin (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide Crystalline Digitalin CP4071 Cardidigin DIGITOXIN Digitoxin |
|
| Definitions |
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2634 |
|
| Accepted_Therapeutic_Use_For |
Atrial Fibrillation; Atrial Flutter; Congestive Heart Failure; Supraventricular Tachyarrhythmias.
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|
| ALT_DEFINITION |
A substance that is being studied as a treatment for cancer.
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|
| CAS_Registry |
71-63-6
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|
| CHEBI_ID |
CHEBI:28544
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|
| Chemical_Formula |
C41H64O13
|
|
| code |
C2634
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC
|
|
| DEFINITION |
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
|
|
| FDA_UNII_Code |
E90NZP2L9U
|
|
| FULL_SYN |
Crystodigin (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide Crystalline Digitalin CP4071 Cardidigin DIGITOXIN Digitoxin
|
|
| Is_Value_For_GDC_Property | ||
| label |
Digitoxin
|
|
| Legacy Concept Name |
Digitoxin
|
|
| Maps_To |
Digitoxin
|
|
| NCI_Drug_Dictionary_ID |
38332
|
|
| NSC Number |
7529
|
|
| PDQ_Closed_Trial_Search_ID |
38332
|
|
| PDQ_Open_Trial_Search_ID |
38332
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|
| Preferred_Name |
Digitoxin
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|
| prefixIRI |
Thesaurus:C2634
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0012258
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|
| subClassOf |
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