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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Valganciclovir | |
| Synonyms |
VALGANCICLOVIR valganciclovir L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl Ester Valganciclovir |
|
| Definitions |
A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2629 |
|
| Accepted_Therapeutic_Use_For |
Cytomegalovirus retinitis
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|
| ALT_DEFINITION |
An antiviral agent that is being studied as a treatment for AIDS-related cytomegalovirus. It is changed in the body to ganciclovir.
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|
| CAS_Registry |
175865-60-8
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|
| CHEBI_ID |
CHEBI:63635
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|
| code |
C2629
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)
|
|
| Display_Name |
Valganciclovir
|
|
| FDA_UNII_Code |
GCU97FKN3R
|
|
| FULL_SYN |
VALGANCICLOVIR valganciclovir L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl Ester Valganciclovir
|
|
| Has_Salt_Form | ||
| label |
Valganciclovir
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|
| Legacy Concept Name |
Valganciclovir
|
|
| NCI_Drug_Dictionary_ID |
38289
|
|
| PDQ_Closed_Trial_Search_ID |
38289
|
|
| PDQ_Open_Trial_Search_ID |
38289
|
|
| Preferred_Name |
Valganciclovir
|
|
| prefixIRI |
Thesaurus:C2629
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|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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|
| UMLS_CUI |
C0909381
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|
| subClassOf |
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