National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Pegylated Interferon Alfa
Synonyms

Pegylated Interferon Alfa

PEG-interferon alfa

PEG-IFN-a
Definitions

A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2491
Accepted_Therapeutic_Use_For

Hepatitis C.
code

C2491
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

CTRP

GDC
DEFINITION

A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
Display_Name

Pegylated Interferon Alfa
FULL_SYN

Pegylated Interferon Alfa

PEG-interferon alfa

PEG-IFN-a
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Pegylated Interferon Alfa
Legacy Concept Name

Pegylated_Interferon_Alfa
Maps_To

Pegylated Interferon Alfa
NCI_Drug_Dictionary_ID

43151
PDQ_Closed_Trial_Search_ID

43151
PDQ_Open_Trial_Search_ID

43151
Preferred_Name

Pegylated Interferon Alfa
prefixIRI

Thesaurus:C2491
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0907160
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C225
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