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National Cancer Institute Thesaurus
| Preferred Name | Recombinant Interferon Alfa | |
| Synonyms |
Lymphoblast Interferon Leukocyte Interferon alpha-Interferon Recombinant Interferon Alfa Interferon Alfa Lymphoblastoid Interferon Alpha Interferon Alferon |
|
| Definitions |
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C225 |
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| Accepted_Therapeutic_Use_For |
See specific agents.
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|
| code |
C225
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
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| Contributing_Source |
CTRP GDC
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|
| DEFINITION |
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
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|
| Display_Name |
Recombinant Interferon Alfa
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|
| FULL_SYN |
Lymphoblast Interferon Leukocyte Interferon alpha-Interferon Recombinant Interferon Alfa Interferon Alfa Lymphoblastoid Interferon Alpha Interferon Alferon
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|
| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Alfa
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|
| Legacy Concept Name |
Therapeutic_Interferon_Alfa
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|
| Maps_To |
Recombinant Interferon Alfa
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| NCI_Drug_Dictionary_ID |
40467
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|
| PDQ_Closed_Trial_Search_ID |
40467
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|
| PDQ_Open_Trial_Search_ID |
40467
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|
| Preferred_Name |
Recombinant Interferon Alfa
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|
| prefixIRI |
Thesaurus:C225
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C0002199
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|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000040467 | PDQ | LOOM |
| http://purl.obolibrary.org/obo/NCIT_C225 | BERO | LOOM |