National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Recombinant Interferon Alfa
Synonyms

Lymphoblast Interferon

Leukocyte Interferon

alpha-Interferon

Recombinant Interferon Alfa

Interferon Alfa

Lymphoblastoid Interferon

Alpha Interferon

Alferon
Definitions

A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C225
Accepted_Therapeutic_Use_For

See specific agents.
code

C225
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

CTRP

GDC
DEFINITION

A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
Display_Name

Recombinant Interferon Alfa
FULL_SYN

Lymphoblast Interferon

Leukocyte Interferon

alpha-Interferon

Recombinant Interferon Alfa

Interferon Alfa

Lymphoblastoid Interferon

Alpha Interferon

Alferon
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Recombinant Interferon Alfa
Legacy Concept Name

Therapeutic_Interferon_Alfa
Maps_To

Recombinant Interferon Alfa
NCI_Drug_Dictionary_ID

40467
PDQ_Closed_Trial_Search_ID

40467
PDQ_Open_Trial_Search_ID

40467
Preferred_Name

Recombinant Interferon Alfa
prefixIRI

Thesaurus:C225
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C0002199
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1971

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C584
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