National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Liposomal Daunorubicin Citrate
Synonyms

Liposomal Daunorubicin

Daunorubicin Liposomal

Daunorubicin Citrate Liposome Injection

Liposomal Daunorubicin Citrate

Daunorubicin (Liposomal)

Daunorubicin liposomal

DaunoXome
Definitions

A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2213
Accepted_Therapeutic_Use_For

Acute Nonlymphocytic Leukemia; Acute Lymphocytic Leukemia; Advanced HIV-associated Karposi Sarcoma.
code

C2213
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

CTRP

GDC

HemOnc

PCDC
DEFINITION

A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.
Display_Name

Liposomal Daunorubicin Citrate
FULL_SYN

Liposomal Daunorubicin

Daunorubicin Liposomal

Daunorubicin Citrate Liposome Injection

Liposomal Daunorubicin Citrate

Daunorubicin (Liposomal)

Daunorubicin liposomal

DaunoXome
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18434
Is_PCDC_AML_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Liposomal Daunorubicin Citrate
Legacy Concept Name

Liposomal_Daunorubicin_Citrate
Maps_To

Liposomal Daunorubicin Citrate
NCI_Drug_Dictionary_ID

37796
NSC Number

697732
PDQ_Closed_Trial_Search_ID

37796
PDQ_Open_Trial_Search_ID

37796
Preferred_Name

Liposomal Daunorubicin Citrate
prefixIRI

Thesaurus:C2213
Semantic_Type

Organic Chemical

Antibiotic
UMLS_CUI

C0717668
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1594
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