National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Fibroblast Growth Factor 1
Synonyms

Beta-Endothelial Cell Growth Factor

Prostatropin

Heparin Binding Growth Factor 1

Endothelial Cell Growth Factor, Beta

Endothelial Cell Growth Factor, Alpha

Endothelial Cell Growth Factor

Acidic Fibroblast Growth Factor

Heparin Binding Growth Factor-1

Fibroblast Growth Factor 1

Alpha Fibroblast Growth Factor

ECGF

FGF-1

FGF1

HBGF-1

aFGF

Definitions

Fibroblast growth factor 1 (17 aa, ~155 kDa) is encoded by the human FGF1 gene. This protein plays a role in cell proliferation, angiogenesis, cell differentiation, and cell migration.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20548

code

C20548

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

Fibroblast growth factor 1 (17 aa, ~155 kDa) is encoded by the human FGF1 gene. This protein plays a role in cell proliferation, angiogenesis, cell differentiation, and cell migration.

DesignNote

Fibroblast growth factor 1 lacks a cleavable signal sequence; it is transported through the cytoplasm to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and protein S100-A13. (UniProt)

Display_Name

Fibroblast Growth Factor 1

FULL_SYN

Beta-Endothelial Cell Growth Factor

Prostatropin

Heparin Binding Growth Factor 1

Endothelial Cell Growth Factor, Beta

Endothelial Cell Growth Factor, Alpha

Endothelial Cell Growth Factor

Acidic Fibroblast Growth Factor

Heparin Binding Growth Factor-1

Fibroblast Growth Factor 1

Alpha Fibroblast Growth Factor

ECGF

FGF-1

FGF1

HBGF-1

aFGF

label

Fibroblast Growth Factor 1

Legacy Concept Name

Fibroblast_Growth_Factor-1

OMIM_Number

131220

Preferred_Name

Fibroblast Growth Factor 1

prefixIRI

Thesaurus:C20548

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

P05230

UMLS_CUI

C0079349

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20426

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