National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Interferon

Synonyms

Human Fibroblast Interferon

Human Lymphoblastoid Interferon

Human Leukocyte Interferon

IFN

Interferon

interferon

Definitions

Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20493

ALT_DEFINITION

A biological response modifier (a substance that can improve the body's natural response to infection and disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and -gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.

code

C20493

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179478

Contributing_Source

CTRP

GDC

PCDC

DEFINITION

Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)

Display_Name

Interferon

FULL_SYN

Human Fibroblast Interferon

Human Lymphoblastoid Interferon

Human Leukocyte Interferon

IFN

Interferon

interferon

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Interferon

Legacy Concept Name

Interferon

Maps_To

Interferon

Preferred_Name

Interferon

prefixIRI

Thesaurus:C20493

Semantic_Type

Amino Acid, Peptide, or Protein

Immunologic Factor

UMLS_CUI

C0021747

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20464

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_52999 CHEBI LOOM
https://w3id.org/codo#COVIDRO_Interferon CODO LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Interferon SEPON LOOM
http://www.co-ode.org/ontologies/galen#Interferon GALEN LOOM
http://purl.obolibrary.org/obo/BE_Interferon BE LOOM
http://purl.bioontology.org/ontology/CSP/1553-6680 CRISP LOOM
http://purl.bioontology.org/ontology/LNC/LP16468-8 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022612 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C20493 COVID-19 LOOM
http://purl.obolibrary.org/obo/NCIT_C20493 BERO LOOM
http://purl.obolibrary.org/obo/IMR_0000027 HOIP LOOM
http://purl.obolibrary.org/obo/IMR_0000027 TXPO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU021353 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/F-CB500 SNMI LOOM
http://www.projecthalo.com/aura#Interferon AURA LOOM
http://purl.bioontology.org/ontology/VANDF/4019787 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0021747 OCHV LOOM
http://purl.jp/bio/4/id/200906086000422990 IOBC LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00810 COID LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/49327004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_52999 BERO LOOM
http://scai.fraunhofer.de/CSEO#CSEO_00000878 CSEO LOOM
http://purl.bioontology.org/ontology/ATC/S01AD05 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000022612 ODAE LOOM
http://www.stanford.edu/~coulet/phare.owl#Interferon PHARE LOOM