National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Thymic T-Cell Selection
Synonyms

Thymic T-Cell Selection

Thymocyte Selection

Definitions

Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19064

code

C19064

DEFINITION

Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.

FULL_SYN

Thymic T-Cell Selection

Thymocyte Selection

label

Thymic T-Cell Selection

Legacy Concept Name

Thymocyte_Selection

Preferred_Name

Thymic T-Cell Selection

prefixIRI

Thesaurus:C19064

Semantic_Type

Cell Function

UMLS_CUI

C1515433

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19317

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