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National Cancer Institute Thesaurus
| Preferred Name | Pegfilgrastim | |
| Synonyms |
Filgrastim SD-01 Pegfilgrastim-bmez Pegfilgrastim Biosimilar Nyvepria Pegfilgrastim-cbqv Pegfilgrastim-apgf PF-06881894 SD-01 sustained duration G-CSF Pegfilgrastim-jmdb Pegfilgrastim PEG-filgrastim pegfilgrastim-bmez Pegylated Granulocyte Colony Stimulating Factor pegfilgrastim-apgf filgrastim-SD/01 pegfilgrastim Pegfilgrastim Biosimilar Pegcyte PEGFILGRASTIM pegfilgrastim-cbqv Pegfilgrastim Biosimilar Ziextenzo Pegylated G-CSF Pegfilgrastim Biosimilar PF-06881894 Pegfilgrastim Biosimilar Udenyca Pegfilgrastim Biosimilar HSP-130 Pegylated GCSF Fulphila HSP-130 Jinyouli Neulasta Neulastim Neupopeg Nyvepria Pegcyte SD-01 Udenyca Ziextenzo |
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| Definitions |
A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1854 |
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| Accepted_Therapeutic_Use_For |
Chemotherapy-induced neutropenia
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|
| ALT_DEFINITION |
A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.
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| CAS_Registry |
208265-92-3
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| Chemical_Formula |
C3H8NO(C2H4O)n
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| code |
C1854
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186329 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc PCDC
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|
| DEFINITION |
A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)
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|
| Display_Name |
Pegfilgrastim
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|
| FDA_UNII_Code |
3A58010674
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|
| FULL_SYN |
Filgrastim SD-01 Pegfilgrastim-bmez Pegfilgrastim Biosimilar Nyvepria Pegfilgrastim-cbqv Pegfilgrastim-apgf PF-06881894 SD-01 sustained duration G-CSF Pegfilgrastim-jmdb Pegfilgrastim PEG-filgrastim pegfilgrastim-bmez Pegylated Granulocyte Colony Stimulating Factor pegfilgrastim-apgf filgrastim-SD/01 pegfilgrastim Pegfilgrastim Biosimilar Pegcyte PEGFILGRASTIM pegfilgrastim-cbqv Pegfilgrastim Biosimilar Ziextenzo Pegylated G-CSF Pegfilgrastim Biosimilar PF-06881894 Pegfilgrastim Biosimilar Udenyca Pegfilgrastim Biosimilar HSP-130 Pegylated GCSF Fulphila HSP-130 Jinyouli Neulasta Neulastim Neupopeg Nyvepria Pegcyte SD-01 Udenyca Ziextenzo
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| Is_Value_For_GDC_Property | ||
| label |
Pegfilgrastim
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| Legacy Concept Name |
Pegfilgrastim
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|
| Maps_To |
Pegfilgrastim
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| NCI_Drug_Dictionary_ID |
37807
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| NSC Number |
725961
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| PDQ_Closed_Trial_Search_ID |
37807
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| PDQ_Open_Trial_Search_ID |
37807
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| Preferred_Name |
Pegfilgrastim
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| prefixIRI |
Thesaurus:C1854
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C1136535
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| subClassOf |
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