Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Lepirudin | |
| Synonyms |
Recombinant Hirudin LEPIRUDIN Lepirudin Refludan lepirudin |
|
| Definitions |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1839 |
|
| ALT_DEFINITION |
A drug that inhibits blood clotting. It is being studied in cancer treatment.
|
|
| CAS_Registry |
138068-37-8
|
|
| Chemical_Formula |
C287H440N80O111S6
|
|
| code |
C1839
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
|
| Contributing_Source |
FDA HemOnc
|
|
| DEFINITION |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.
|
|
| FDA_UNII_Code |
Y43GF64R34
|
|
| FULL_SYN |
Recombinant Hirudin LEPIRUDIN Lepirudin Refludan lepirudin
|
|
| label |
Lepirudin
|
|
| Legacy Concept Name |
Lepirudin
|
|
| NCI_Drug_Dictionary_ID |
43356
|
|
| PDQ_Closed_Trial_Search_ID |
43356
|
|
| PDQ_Open_Trial_Search_ID |
43356
|
|
| Preferred_Name |
Lepirudin
|
|
| prefixIRI |
Thesaurus:C1839
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
|
|
| UMLS_CUI |
C0772394
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping