loading...| Preferred Name | Paroxetine Hydrochloride | |
| Synonyms |
PAROXETINE HYDROCHLORIDE ANHYDROUS (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride paroxetine hydrochloride Paroxetine Hydrochloride Paxil Paxil CR |
|
| Definitions |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1837 |
|
| Accepted_Therapeutic_Use_For |
Depression |
|
| ALT_DEFINITION |
A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI). |
|
| CAS_Registry |
78246-49-8 |
|
| Chemical_Formula |
C19H20FNO3.HCl |
|
| code |
C1837 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. |
|
| FDA_UNII_Code |
3I3T11UD2S |
|
| FULL_SYN |
PAROXETINE HYDROCHLORIDE ANHYDROUS (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride paroxetine hydrochloride Paroxetine Hydrochloride Paxil Paxil CR |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Paroxetine Hydrochloride |
|
| Legacy Concept Name |
Paroxetine_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
42793 |
|
| PDQ_Closed_Trial_Search_ID |
42793 |
|
| PDQ_Open_Trial_Search_ID |
42793 |
|
| Preferred_Name |
Paroxetine Hydrochloride |
|
| prefixIRI |
Thesaurus:C1837 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0771019 |
|
| subClassOf |