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National Cancer Institute Thesaurus
| Preferred Name | Infliximab | |
| Synonyms |
Avakine INFLIXIMAB Infliximab Remicade Remsima cA2 infliximab |
|
| Definitions |
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1789 |
|
| Accepted_Therapeutic_Use_For |
Ankylosis spondylitis; Crohns disease; Plaque psoriasis; Rheumatoid arthritis; Sarcoidosis
|
|
| ALT_DEFINITION |
A monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer. It belongs to the family of drugs called monoclonal antibodies.
|
|
| CAS_Registry |
170277-31-3
|
|
| code |
C1789
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
|
|
| Display_Name |
Infliximab
|
|
| FDA_UNII_Code |
B72HH48FLU
|
|
| FULL_SYN |
Avakine INFLIXIMAB Infliximab Remicade Remsima cA2 infliximab
|
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Infliximab
|
|
| Legacy Concept Name |
Infliximab
|
|
| Maps_To |
Infliximab
|
|
| NCI_Drug_Dictionary_ID |
38698
|
|
| NSC Number |
728729
|
|
| PDQ_Closed_Trial_Search_ID |
38698
|
|
| PDQ_Open_Trial_Search_ID |
38698
|
|
| Preferred_Name |
Infliximab
|
|
| prefixIRI |
Thesaurus:C1789
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
|
|
| UMLS_CUI |
C0666743
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|
| subClassOf |
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